Buprenorphine Injection I.P., COPIGESIC

Opioid Analgesic – Narcotic Pain Reliever

COPIGESIC (Buprenorphine Injection I.P.) is a sterile injectable opioid analgesic formulation manufactured according to Indian Pharmacopoeia (I.P.) standards. Buprenorphine is a partial opioid agonist that provides potent and long-lasting pain relief with a favorable safety profile compared to full opioid agonists. This injectable is widely used in hospital, surgical, oncology, and emergency care settings for effective pain control. Its strong receptor affinity and extended duration of action make it suitable for acute and severe pain management protocols.

Key Information

Active Ingredient Buprenorphine

Dosage Form Injection

Pack Size 25 x 2 mL Ampoules

Storage Protect from light, store at controlled room temp.

Benefits

Powerful and long-lasting analgesic effect

Effective for postoperative and cancer pain

Reduced risk of severe respiratory depression compared to full opioid agonists

Suitable for hospital-based acute pain management

I.P. quality-compliant injectable formulation

Usage Instructions

Administered intravenously (IV) or intramuscularly (IM) by trained healthcare professionals

Dosage and frequency depend on patient condition and pain severity

Should be used under strict medical supervision

Monitor respiratory and cardiovascular function during use

Mechanism of Action

Buprenorphine acts as a partial agonist at mu-opioid receptors and an antagonist at kappa receptors. It binds strongly to opioid receptors, reducing pain perception while producing less euphoria and respiratory depression compared to full opioid agonists.

Indications

Buprenorphine Injection I.P. (COPIGESIC) is indicated for:

Moderate to severe pain management

Postoperative pain relief

Trauma-related pain

Cancer-associated pain

Acute severe musculoskeletal pain

Pain where opioid analgesic therapy is required

Side Effects

Common and potential side effects include:

Nausea and vomiting

Drowsiness

Dizziness

Constipation

Sweating

Respiratory depression (dose-related)

Hypotension

Precautions

Use cautiously in elderly patients

Monitor patients with liver impairment

Avoid concurrent use with CNS depressants unless medically supervised

Risk of dependence with prolonged use

Use in pregnancy only if clearly indicated

Contraindications

Hypersensitivity to buprenorphine or other opioids

Severe respiratory depression

Acute bronchial asthma

Severe hepatic impairment

Patients with paralytic ileus

Frequently Asked Questions

Find answers to common questions about Buprenorphine Injection I.P., COPIGESIC

1 What is COPIGESIC Buprenorphine Injection used for?

It is used for moderate to severe pain management, especially in postoperative and cancer-related pain.

2 Is Buprenorphine stronger than morphine?

Buprenorphine is a potent opioid analgesic with strong receptor affinity and long duration of action.

3 Can it cause dependence?

Yes, prolonged use may lead to physical dependence. It should be used strictly under medical supervision.

4 How long does Buprenorphine Injection last?

It has a relatively long duration of action compared to many other opioid analgesics.

5 Is COPIGESIC compliant with pharmacopoeial standards?

Yes, it is manufactured as per Indian Pharmacopoeia (I.P.) standards.