Clindamycin Phosphate 1% & Nicotinamide 4% Gel

Topical Anti-Acne Combination – Antibiotic & Anti-Inflammatory Agent

Clindamycin Phosphate 1% & Nicotinamide 4% Gel is a topical anti-acne formulation combining an antibiotic and an anti-inflammatory agent. Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis, targeting acne-causing bacteria such as Cutibacterium acnes. Nicotinamide (Vitamin B3) helps reduce inflammation, regulate sebum production, and improve skin barrier function. This dual-action acne gel provides antibacterial control along with anti-inflammatory benefits, making it suitable for dermatological use in adolescents and adults. The non-greasy gel base ensures easy application and improved patient compliance.

Key Information

Active Ingredient Clindamycin Phosphate + Nicotinamide

Dosage Form Cream

Pack Size 15 g

Storage Store below 25°C∘C. Do not freeze.

Benefits

Reduces acne-causing bacteria

Controls inflammation and redness

Helps regulate oil (sebum) production

Improves overall skin texture

Non-comedogenic and easy-to-apply gel formulation

Suitable for routine dermatological use

Usage Instructions

For external use only

Apply a thin layer to clean, dry affected area once or twice daily as directed by a healthcare professional

Avoid contact with eyes, mouth, and mucous membranes

Wash hands after application

Mechanism of Action

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, reducing bacterial growth associated with acne.
Nicotinamide exhibits anti-inflammatory properties, reduces sebum production, and supports skin barrier repair, enhancing overall acne management.

Indications

Clindamycin Phosphate 1% & Nicotinamide 4% Gel is indicated for:

Mild to moderate acne vulgaris

Inflammatory acne lesions (papules and pustules)

Acne associated with excess sebum production

Bacterial skin infections related to acne

Redness and inflammation associated with acne breakouts

Side Effects

Possible side effects may include:

Mild skin dryness

Burning or stinging sensation

Itching

Skin irritation

Rare cases of antibiotic-associated diarrhea

Precautions

Avoid excessive sun exposure; use sunscreen if required

Discontinue use if severe irritation occurs

Use cautiously in patients with history of gastrointestinal disorders

Not recommended for use on broken or severely damaged skin

Use under medical supervision

Contraindications

Hypersensitivity to clindamycin, lincomycin, nicotinamide, or any excipients

History of antibiotic-associated colitis

Severe inflammatory bowel disease (use with caution)

Frequently Asked Questions

Find answers to common questions about Clindamycin Phosphate 1% & Nicotinamide 4% Gel

1 What is Clindamycin & Nicotinamide Gel used for?

It is used to treat mild to moderate acne and inflammatory skin lesions.

2 How long does it take to show results?

Visible improvement may be seen within a few weeks of regular use.

3 Can it be used for oily skin?

Yes, it helps regulate sebum production and is suitable for oily and acne-prone skin.

4 Is it safe for long-term use?

Use should be as directed by a dermatologist to prevent antibiotic resistance.

5 Can it be used with other acne treatments?

Consult a healthcare professional before combining with other topical or oral acne medications.