Imipenem & Cilastatin for Injection U.S.P.

Carbapenem Antibiotic Broad-Spectrum Antibacterial Agent Beta-Lactam Antibiotic Combination

Imipenem & Cilastatin for Injection U.S.P. is a broad-spectrum carbapenem antibiotic combination used to treat severe and life-threatening bacterial infections. Imipenem is a powerful antibiotic that kills bacteria by inhibiting bacterial cell wall synthesis. Cilastatin is added to prevent the breakdown of imipenem in the kidneys, allowing the antibiotic to remain active in the body for a longer time. This combination is highly effective against a wide range of Gram-positive and Gram-negative bacteria, including organisms resistant to many other antibiotics. It is commonly used in hospitals for the treatment of serious infections of the lungs, abdomen, urinary tract, skin, and bloodstream.

Key Information

Active Ingredient Imipenem, Cilastatin

Dosage Form Dry Injection

Pack Size 1 Vial (100 mg)

Storage Store below 25°C. Protect from light and moisture

Benefits

Imipenem + Cilastatin injection provides several therapeutic benefits:

Effective against a wide range of bacteria

Useful in severe and hospital-acquired infections

Helps treat antibiotic-resistant bacterial infections

Provides rapid bactericidal action

Enhances antibiotic stability in the body

Usage Instructions

This injection should be administered by a qualified healthcare professional.

It is usually given intravenously (IV) in a hospital or clinical setting.

The dosage depends on the type and severity of infection and patient condition.

Do not self-administer the injection.

Mechanism of Action

Imipenem works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Cilastatin inhibits the enzyme renal dehydropeptidase I, which normally breaks down imipenem in the kidneys. By blocking this enzyme, cilastatin increases the effectiveness and duration of imipenem, allowing it to fight infections more effectively.

Indications

Imipenem & Cilastatin Injection is indicated for:

Severe respiratory tract infections

Urinary tract infections (UTIs)

Intra-abdominal infections

Skin and soft tissue infections

Septicemia (bloodstream infections)

Bone and joint infections

Complicated bacterial infections

Side Effects

Some patients may experience side effects such as:

Nausea

Vomiting

Diarrhea

Injection site irritation

Skin rash

Headache

Serious allergic reactions are rare but require immediate medical attention.

Precautions

Inform your doctor if you have kidney disease or a history of seizures.

Use cautiously in patients with allergy to beta-lactam antibiotics.

Dose adjustment may be required in patients with renal impairment.

Use during pregnancy or breastfeeding only if prescribed by a doctor.

Contraindications

This medicine should not be used in the following conditions:

Hypersensitivity to imipenem, cilastatin, or carbapenem antibiotics

Severe allergy to beta-lactam antibiotics

History of serious penicillin or cephalosporin allergy

Frequently Asked Questions

Find answers to common questions about Imipenem & Cilastatin for Injection U.S.P.

1 What is Imipenem & Cilastatin Injection used for?

It is used to treat serious bacterial infections such as respiratory, abdominal, urinary, and bloodstream infections.

2 Why is Cilastatin combined with Imipenem?

Cilastatin prevents the breakdown of imipenem in the kidneys, increasing its effectiveness.

3 How is Imipenem & Cilastatin administered?

It is given intravenously (IV) by a healthcare professional in hospital settings.

4 Is Imipenem a strong antibiotic?

Yes, it is a powerful carbapenem antibiotic used for severe or resistant bacterial infections.

5 What are common side effects of Imipenem & Cilastatin?

Common side effects include nausea, vomiting, diarrhea, rash, and injection site irritation.