Phytonadione Injectable Emulsion USP 10mg/mL

Vitamin Supplement – Vitamin K1 / Hemostatic Agent

Phytonadione Injectable Emulsion USP 10 mg/mL is a sterile preparation of Vitamin K1, formulated as an injectable emulsion for parenteral administration. It is essential for the synthesis of clotting factors II, VII, IX, and X, which are required for normal blood coagulation. Manufactured in compliance with United States Pharmacopeia (USP) standards, this injectable emulsion ensures high purity, stability, and therapeutic effectiveness. It is widely used in hospital, neonatal, and emergency settings for rapid correction of Vitamin K deficiency and management of anticoagulant-related bleeding. Produced under strict pharmaceutical quality control systems, this formulation supports safe and reliable coagulation management in clinical practice.

Key Information

Active Ingredient Phytonadione (Vitamin K1)

Dosage Form Injection

Pack Size 0.5mL, 1mL Ampoule

Storage 15°C - 30°C (Protect from light)

Benefits

Rapid correction of Vitamin K deficiency

Supports normal blood clotting function

Effective reversal of warfarin-induced anticoagulation

Essential for newborn prophylaxis

USP-compliant quality assurance

Usage Instructions

Administered intramuscularly, intravenously, or subcutaneously as directed by a healthcare professional

Dosage depends on indication, patient age, and severity of deficiency

IV administration should be given slowly to minimize adverse reactions

For professional medical use only

Mechanism of Action

Phytonadione (Vitamin K1) acts as a cofactor in the hepatic synthesis of vitamin K–dependent clotting factors (II, VII, IX, and X). It restores normal coagulation by enabling the activation of these clotting proteins.

Indications

Phytonadione Injectable Emulsion USP 10 mg/mL is indicated for:

Treatment and prevention of Vitamin K deficiency

Management of hypoprothrombinemia due to anticoagulant therapy (e.g., warfarin)

Reversal of anticoagulant-induced bleeding

Prevention and treatment of hemorrhagic disease of the newborn

Correction of clotting factor deficiencies related to malabsorption or liver disease

Side Effects

Possible side effects may include:

Injection site reactions

Flushing or sweating

Dizziness

Allergic reactions

Rare: Anaphylactoid reactions with rapid IV administration

Precautions

Administer under medical supervision

Avoid rapid intravenous injection

Monitor coagulation parameters (e.g., INR) when used to reverse anticoagulation

Use caution in patients with liver disease

Emergency support should be available in case of hypersensitivity reactions

Contraindications

Known hypersensitivity to phytonadione (Vitamin K1) or any component of the formulation

Severe allergic reaction to previous Vitamin K injections

Use with caution in patients with a history of hypersensitivity to emulsified preparations

Frequently Asked Questions

Find answers to common questions about Phytonadione Injectable Emulsion USP 10mg/mL

1 What is Phytonadione Injectable Emulsion used for?

It is used to treat Vitamin K deficiency and reverse anticoagulant-induced bleeding.

2 Is this injection used in newborns?

Yes, it is commonly administered to prevent hemorrhagic disease of the newborn.

3 How quickly does it work?

It helps restore clotting factor synthesis, with effects depending on severity and patient condition.

4 Is this product USP compliant?

Yes, it is manufactured according to United States Pharmacopeia standards.

5 Does it require monitoring?

Yes, coagulation parameters such as INR should be monitored when used to reverse anticoagulant therapy.