Neostigmine Injection BP 0.5mg/mL

Anticholinesterase Agent – Neuromuscular Block Reversal Agent

Neostigmine Injection BP 0.5mg/mL is a sterile, clear injectable formulation manufactured according to British Pharmacopoeia (BP) standards. It is a reversible cholinesterase inhibitor widely used in anesthesia and critical care settings. This injectable is primarily administered to reverse the effects of non-depolarizing muscle relaxants following surgical procedures. It restores neuromuscular transmission by increasing acetylcholine levels at the neuromuscular junction. Neostigmine Injection is an essential product in operating theatres, emergency units, and intensive care units, ensuring effective and controlled recovery of muscle function.

Key Information

Active Ingredient Neostigmine Methylsulphate

Dosage Form Injection

Pack Size 1mL, 5mL Ampoule

Storage 15°C - 30°C

Benefits

Effective reversal of neuromuscular blockade

Rapid restoration of muscle strength

Essential support in anesthesia practice

Reliable BP-compliant injectable formulation

Suitable for hospital and surgical use

Usage Instructions

Administered intravenously (IV) or intramuscularly (IM) by trained healthcare professionals

Often given in combination with an anticholinergic agent (e.g., atropine or glycopyrrolate) to reduce muscarinic side effects

Dosage depends on patient condition and clinical indication

Continuous monitoring of respiratory and cardiac function is recommended

Mechanism of Action

Neostigmine inhibits the enzyme acetylcholinesterase, preventing the breakdown of acetylcholine. This increases acetylcholine concentration at the neuromuscular junction, enhancing cholinergic transmission and reversing muscle paralysis caused by non-depolarizing neuromuscular blocking agents.

Indications

Neostigmine Injection BP 0.5mg/mL is indicated for:

Reversal of non-depolarizing neuromuscular blockade after surgery

Management of myasthenia gravis

Treatment of postoperative urinary retention

Management of postoperative abdominal distension (paralytic ileus)

Side Effects

Possible side effects include:

Bradycardia

Increased salivation

Nausea and vomiting

Abdominal cramps

Sweating

Bronchospasm (rare)

Precautions

Use cautiously in patients with asthma

Monitor heart rate during administration

Avoid in mechanical obstruction conditions

Careful dose titration in elderly patients

Use under strict medical supervision

Contraindications

Hypersensitivity to neostigmine or bromides

Mechanical obstruction of gastrointestinal or urinary tract

Peritonitis

Severe bradycardia

Caution in asthma patients