Metoclopramide Injection BP 10mg/2mL

Antiemetic and Prokinetic Agent – Dopamine Antagonist

Metoclopramide Injection BP 10mg/2mL is a sterile injectable formulation manufactured according to British Pharmacopoeia (BP) standards. It is a dopamine D2 receptor antagonist with both antiemetic and prokinetic properties. This injectable is widely used in hospital, emergency, and oncology settings for rapid control of nausea and vomiting when oral therapy is not suitable. It also enhances gastric motility, making it effective in conditions like gastroparesis and delayed gastric emptying. Metoclopramide Injection BP ensures reliable therapeutic action, quality assurance, and suitability for hospital-based care.

Key Information

Active Ingredient Metoclopramide HCl 5mg/mL

Dosage Form Injection

Pack Size 2mL Ampoule

Storage 15°C - 30°C

Benefits

Rapid relief from nausea and vomiting

Dual action: antiemetic and prokinetic

Effective in chemotherapy and postoperative settings

Suitable for IV and IM administration

BP-compliant sterile injectable formulation

Usage Instructions

Administered intravenously (IV) or intramuscularly (IM) by healthcare professionals

Dosage depends on patient age, weight, and clinical condition

Slow IV administration recommended

Short-term use is generally advised to reduce risk of extrapyramidal reactions

Mechanism of Action

Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ), preventing nausea and vomiting. It also enhances acetylcholine release in the gastrointestinal tract, improving gastric emptying and intestinal motility.

Indications

Metoclopramide Injection BP 10mg/2mL is indicated for:

Prevention and treatment of nausea and vomiting

Chemotherapy-induced nausea and vomiting (CINV)

Postoperative nausea and vomiting (PONV)

Drug-induced vomiting

Diabetic gastroparesis

Gastroesophageal reflux disease (GERD) requiring parenteral therapy

Side Effects

Possible side effects include:

Drowsiness

Restlessness

Diarrhea

Extrapyramidal symptoms (e.g., dystonia)

Tardive dyskinesia (rare with prolonged use)

Elevated prolactin levels

Precautions

Use cautiously in elderly patients

Avoid long-term continuous use

Monitor patients with Parkinson’s disease

Dose adjustment may be required in renal impairment

Use under medical supervision only

Contraindications

Hypersensitivity to metoclopramide

Gastrointestinal obstruction, perforation, or hemorrhage

Pheochromocytoma

Epilepsy

History of tardive dyskinesia

Concomitant use with levodopa

Frequently Asked Questions

Find answers to common questions about Metoclopramide Injection BP 10mg/2mL

1 What is Metoclopramide Injection BP used for?

It is used to treat nausea, vomiting, and gastric motility disorders.

2 Can it be used for chemotherapy patients?

Yes, it is commonly used for chemotherapy-induced nausea and vomiting.

3 Does it improve gastric emptying?

Yes, it has prokinetic properties that enhance gastric motility.

4 Is it safe for long-term use?

Long-term use is generally not recommended due to risk of movement disorders.

5 Is this product BP compliant?

Yes, it is manufactured according to British Pharmacopoeia standards.