Amikacin Injection BP 500mg/2mL

Aminoglycoside Antibiotic Anti-infective Injectable Broad-Spectrum Antibacterial Agent

Amikacin Injection BP 500mg/2mL is a broad-spectrum aminoglycoside antibiotic used to treat serious bacterial infections caused by susceptible gram-negative and some gram-positive organisms. It is commonly used in hospitals for the management of severe infections when other antibiotics may not be effective. This injectable antibiotic works by inhibiting bacterial protein synthesis, which ultimately leads to the death of bacteria. Amikacin is particularly effective against resistant bacterial strains and is widely used for treating infections involving the respiratory tract, urinary tract, bloodstream, bones, joints, and soft tissues. Manufactured according to British Pharmacopoeia (BP) standards, Amikacin Injection ensures high sterility, potency, and consistent therapeutic performance for clinical and hospital use.

Key Information

Active Ingredient Amikacin (as Sulphate)

Dosage Form Injection

Pack Size 2mL Vial

Storage 15°C – 30°C

Benefits

Broad-spectrum antibacterial activity

Effective against resistant gram-negative bacteria

Rapid bactericidal action

Widely used in hospital and critical care settings

Suitable for severe and life-threatening infections

Usage Instructions

Administer under the supervision of a qualified healthcare professional.

Given via intramuscular (IM) injection or slow intravenous infusion.

Dosage depends on patient weight, age, renal function, and severity of infection.

Regular monitoring of kidney function and hearing may be required during treatment.

Mechanism of Action

Amikacin works by binding to the 30S ribosomal subunit of bacteria, preventing the synthesis of essential proteins required for bacterial growth.

This action results in:

Disruption of bacterial protein production

Damage to bacterial cell function

Rapid bacterial cell death

Because of this bactericidal activity, Amikacin is highly effective against severe and resistant bacterial infections.

Indications

Amikacin Injection is indicated for the treatment of serious infections such as:

Sepsis

Pneumonia

Urinary Tract Infection

Bone and joint infections

Skin and soft tissue infections

Intra-abdominal infections

Post-surgical infections

It is particularly effective against bacteria such as:

Pseudomonas aeruginosa

Escherichia coli

Klebsiella pneumoniae

Side Effects

Common:

Injection site pain

Nausea or vomiting

Precautions

Monitor renal function during therapy

Prolonged use may cause ototoxicity or nephrotoxicity

Use cautiously in elderly patients

Avoid concurrent use with other nephrotoxic drugs if possible

Monitor drug levels during long-term treatment

Contraindications

Hypersensitivity to amikacin or other aminoglycoside antibiotics

Known allergy to aminoglycosides

Use cautiously in patients with renal impairment

Frequently Asked Questions

Find answers to common questions about Amikacin Injection BP 500mg/2mL

1 What is Amikacin Injection used for?

It is used to treat severe bacterial infections affecting the lungs, urinary tract, bloodstream, and other body tissues.

2 Is Amikacin effective against resistant bacteria?

Yes, it is commonly used for infections caused by drug-resistant gram-negative bacteria.

3 Can Amikacin affect kidney function?

Yes, prolonged use may affect kidney function, so regular monitoring is recommended.

4 Who should administer Amikacin Injection?

It should be administered by trained healthcare professionals in hospitals or clinical settings.