Amikacin Injection BP 250mg/2mL

Aminoglycoside Antibiotic Anti-infective Injectable Broad-Spectrum Antibacterial Agent

Amikacin Injection BP 250mg/2mL is a broad-spectrum aminoglycoside antibiotic used for the treatment of serious bacterial infections caused by susceptible organisms. It is commonly administered in hospital and clinical settings for infections that require potent antibacterial therapy. This injectable antibiotic works by inhibiting bacterial protein synthesis, resulting in the destruction of bacteria. Amikacin is especially effective against gram-negative pathogens and strains that may be resistant to other antibiotics. Manufactured according to British Pharmacopoeia (BP) standards, Amikacin Injection ensures high sterility, potency, and consistent therapeutic performance, making it suitable for use in hospitals, clinics, and intensive care units.

Key Information

Active Ingredient Amikacin (as Sulphate)

Dosage Form Injection

Pack Size 2mL Vial

Storage 15°C – 30°C

Benefits

Broad-spectrum antibacterial activity

Effective against resistant gram-negative bacteria

Rapid bactericidal action

Suitable for severe infections requiring injectable therapy

Widely used in hospitals and critical care settings

Usage Instructions

Administer only under medical supervision.

Given via intramuscular injection or slow intravenous infusion.

Dosage depends on patient weight, severity of infection, and renal function.

Regular monitoring of kidney function and hearing is recommended during prolonged therapy.

Mechanism of Action

Amikacin works by binding to the 30S ribosomal subunit of bacteria, interfering with protein synthesis.

This results in:

Disruption of bacterial protein production

Impairment of bacterial cellular function

Rapid bactericidal effect leading to elimination of infection

Because of its strong bactericidal activity, Amikacin is widely used in serious and hospital-acquired infections.

Indications

Amikacin Injection is indicated for the treatment of severe infections such as:

Sepsis

Pneumonia

Urinary Tract Infection

Bone and joint infections

Skin and soft tissue infections

Intra-abdominal infections

Post-operative infections

It is effective against bacteria including:

Pseudomonas aeruginosa

Escherichia coli

Klebsiella pneumoniae

Side Effects

Common:

Pain at injection site

Nausea or vomiting

Precautions

Monitor renal function during treatment

Prolonged therapy may cause nephrotoxicity or ototoxicity

Use cautiously in elderly patients

Avoid simultaneous use with other nephrotoxic medications when possible

Monitor drug levels during long-term treatment

Contraindications

Hypersensitivity to amikacin or other aminoglycoside antibiotics

Known allergy to aminoglycosides

Severe renal impairment without proper monitoring

Frequently Asked Questions

Find answers to common questions about Amikacin Injection BP 250mg/2mL

1 What is Amikacin Injection BP 250mg/2mL used for?

It is used to treat serious bacterial infections affecting the lungs, urinary tract, bloodstream, bones, and soft tissues.

2 Who should administer Amikacin Injection?

It should be administered by qualified healthcare professionals in hospitals or clinical settings.

3 Can Amikacin affect kidney function?

Yes, prolonged use may affect kidney function, so regular monitoring is recommended.

4 Is Amikacin effective against resistant bacteria?

Yes, it is particularly effective against many drug-resistant gram-negative bacteria.